Between 2001 and 2006, Erica Cerra had guest roles on several popular and critically acclaimed TV shows including Battlestar Galactica, The L Word, and Smallville. Her other roles included parts in The 4400, The Dead Zone, Reaper, Huff, and Dead Like Me, as well as the Canadian police procedural Cold Squad, the monster-hunting action series Special Unit 2, and the supernatural thriller series The Collector. She also appeared in major cinematic movie releases Man About Town with Ben Affleck and Rebecca Romijn, and Blade:Trinity with Wesley Snipes.
In 2006, she was cast as Deputy Jo Lupo in Eureka, a Syfy series which was broadcast between 2006 and 2012. Cerra was one of the stars of the ensemble cast, with her character playing an integral role throughout the series’ five seasons.
She has since appeared in various guest roles in series such as Warehouse 13, Sanctuary, Supernatural, and Motive. She had a recurring role in the 2014 USA Network series Rush and appeared in the CW series iZombie in 2015.
Cerra appeared in the second season finale of the CW series The 100 which aired on March 11, 2015, as a mysterious A.I. called A.L.I.E. She played the main antagonist during the third season and reprised the role in an episode of the fourth season. Cerra also played Becca, the creator of A.L.I.E., in a flashback storyline.